Here are the things I found for the pain: You MUST inject it into fat. When you go into fat, it's waaay better. Biologics going into muscles burns. My loading doses went into my arms and were horrid. I go into my stomach now and don't feel it as long as I do the test if the stuff on this list. It has to be room temp. I leave it out overnight. Honestly, it's pretty much up to room temp within an hour or two but leaving it longer than 1 day won't make any difference. It has to be injected slowly and I mean very slowly. I put very slight pressure on the plunger to the point it takes me about 3 minutes to inject. Several people have switched from the autopen to the syringe just so they could slow it down and hurt less. I pinch my stomach to inject the needle but once the needle is in, I don't pinch it anymore. I completely remove my left hand because any pressure around the needle makes it worse. The needle bevel needs to be at the top when injecting. This helped me a lot.
Most doctors, nurses and people do dupixent shots the wrong way. Dupixent needs to be injected slowly as fuck! Let it warm up to room temp, grab some nice fatty tissue (I prefer outer thigh pretty far top), angle the needle 45°, jab it in, slowly loosen the grabbed fatty tissue and start pressing the plunger down S L O W L Y. Take your sweet time. I usually take about 30 to 40 seconds at least. If it takes 2 minutes, that's ok as well. The faster you do it, the more it hurts. Do yourself a favor and don't get the pen! Learned the slow trick from my dentist, who does the lidocaine injection so extremely slow, that you literally feel nothing. Give the nerves and surrounding tissue time, to adapt to the pressure of the added fluid! And there is something strange to the mixture itself that burns, if it's injected too fast.
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