Don't worry about finding or facing the DJs. The center of the room, under the disco ball, is the center of the party. Despacio was deliberately and thoughtfully designed to de-escalate the DJ worship that took hold of EDM / DJ culture in the last few decades. The DJ team want Despacio attendees to focus on the music, dance, and on each other. It's a deliberate upending of convention and a return to a pure dancefloor ideal. The goal is to get folks dancing with each other, and it succeeds spectacularly at this.
In the words of one journalist, “Despacio – a concept that equals pure, unadulterated aural ecstasy. The system (named after the Spanish word for 'slow') is one of the world's weightiest, propelled by eight McIntosh stacks and the insane audio knowledge of John Klett, LCD's James Murphy's comrade in audiophilia.” In the words of redditor /u/jorgeandthekraken : "So, first of all, the sound is unreal. Standing in the middle of the dance floor, it's powerful enough that you feel the bass in your chest, but the fidelity is so good that you could have a decent conversation just by raising your voice a bit. It's the best sound I've ever heard in a dance club-like situation.